Christian Brueffer

Senior Bioinformatician

Biography

I work as a Senior Bioinformatician at the cancer diagnostics company SAGA Diagnostics and am affiliated with Lund University in Sweden.

My research focuses on the development of diagnostics based on tumor DNA/RNA deep sequencing (also known as next generation sequencing) to improve breast cancer treatment and survival. Most of my projects are embedded in the Sweden Cancerome Analysis Network–Breast (SCAN-B) study. Additionally I work on improving open source bioinformatics and reproducible research infrastructure by contributing to projects such as conda-forge, Bioconda, and Biopython.

Over the past 20 years I have contributed to a number of open source software projects, most notably the FreeBSD computer operating system. An overview can be found on OpenHub.

Interests

Bioinformatics
Cancer Biology and Diagnostics
Open Source Software
Software Engineering

Education

PhD in Cancer Genomics

Lund University, Sweden
MSc in Bioinformatics

Lund University, Sweden
BSc in Scientific Programming

Aachen University of Applied Sciences, Germany

Projects

PhD Project: RNA Sequencing-based Tools for Breast Cancer Diagnostics

My PhD work in developing RNA sequencing-based diagnostic tools for breast cancer.

SCAN-B MutationExplorer

A web-based application for exploring tumor somatic mutations.

FreeBSD

I have been a developer with the FreeBSD operating system project since 2003. This page collates some related links.

Recent & Upcoming Talks

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May 29, 2020

Defining the Mutational Landscape of 3,217 Primary Breast Cancer Transcriptomes through large-scale RNA-seq within the Sweden Cancerome Analysis Network: Breast Project (SCAN-B; NCT03430492)

Nov 4, 2019

Defining the Mutational Landscape of the Primary Breast Cancer Transcriptome through large-scale RNA-seq in the Sweden Cancerome Analysis Network–Breast (SCAN-B) Project

May 23, 2019

Towards Better Breast Cancer Diagnostics: Large-scale Profiling of Tumor Transcriptomes

See all

Featured Publications

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The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome

Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and …

Christian Brueffer, Sergii Gladchuk, Christof Winter, Johan Vallon-Christersson, Cecilia Hegardt, Jari Häkkinen, Anthony M. George, Yilun Chen, Anna Ehinger, Christer Larsson, Niklas Loman, Martin Malmberg, Lisa Rydén, Åke Borg, Lao H. Saal

The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome

Features of increased malignancy in eosinophilic clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is the most common form of renal cancer. Due to inactivation of the von Hippel–Lindau tumour …

Helén Nilsson, David Lindgren, Håkan Axelson, Christian Brueffer, Lao H. Saal, Jaana Lundgren, Martin Johansson

Features of increased malignancy in eosinophilic clear cell renal cell carcinoma

Clinical Value of RNA Sequencing-Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network–Breast Initiative

In early breast cancer (BC), five conventional biomarkers—estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth …

Christian Brueffer, Johan Vallon-Christersson, Dorthe Grabau, Anna Ehinger, Jari Häkkinen, Cecilia Hegardt, Janne Malina, Yilun Chen, Pär-Ola Bendahl, Jonas Manjer, Martin Malmberg, Christer Larsson, Niklas Loman, Lisa Rydén, Åke Borg, Lao H. Saal

Clinical Value of RNA Sequencing-Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network–Breast Initiative

Christian Brueffer

Senior Bioinformatician

SAGA Diagnostics

Lund University