Breast Cancer

Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer
More than three-quarters of primary breast cancers are positive for estrogen receptor alpha (ER; encoded by the gene ESR1), the most …
Malin Dahlgren, Anthony M. George, Christian Brueffer, Sergii Gladchuk, Yilun Chen, Johan Vallon-Christersson, Cecilia Hegardt, Jari Häkkinen, Lisa Rydén, Martin Malmberg, Christer Larsson, Sofia K. Gruvberger-Saal, Anna Ehinger, Niklas Loman, Åke Borg, Lao H. Saal
PDF Dataset DOI Press Release
Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer
PhD Project: RNA Sequencing-based Tools for Breast Cancer Diagnostics
My PhD work in developing RNA sequencing-based diagnostic tools for breast cancer.
PhD Project: RNA Sequencing-based Tools for Breast Cancer Diagnostics
RNA Sequencing for Molecular Diagnostics in Breast Cancer
Breast cancer is the most common type of cancer in women and, in Sweden, is the most deadly second only to lung cancer. While treatment …
Christian Brueffer
PDF Code Project
RNA Sequencing for Molecular Diagnostics in Breast Cancer
The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome
Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and …
Christian Brueffer, Sergii Gladchuk, Christof Winter, Johan Vallon-Christersson, Cecilia Hegardt, Jari Häkkinen, Anthony M. George, Yilun Chen, Anna Ehinger, Christer Larsson, Niklas Loman, Martin Malmberg, Lisa Rydén, Åke Borg, Lao H. Saal
Preprint PDF Code Dataset Project DOI Press Release
The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome
Defining the Mutational Landscape of 3,217 Primary Breast Cancer Transcriptomes through large-scale RNA-seq within the Sweden Cancerome Analysis Network: Breast Project (SCAN-B; NCT03430492)
May 29, 2020
Project Project
SCAN-B MutationExplorer
A web-based application for exploring tumor somatic mutations.
SCAN-B MutationExplorer
Defining the Mutational Landscape of the Primary Breast Cancer Transcriptome through large-scale RNA-seq in the Sweden Cancerome Analysis Network–Breast (SCAN-B) Project
Nov 4, 2019
Project Project
Detection of circulating tumor cells and circulating tumor DNA before and after mammographic breast compression in a cohort of breast cancer patients scheduled for neoadjuvant treatment
It is not known if mammographic breast compression of a primary tumor causes shedding of tumor cells into the circulatory system. …
Daniel Förnvik, Kristina E. Aaltonen, Yilun Chen, Anthony M. George, Christian Brueffer, Robert Rigo, Niklas Loman, Lao H. Saal, Lisa Rydén
PDF Cite DOI
Detection of circulating tumor cells and circulating tumor DNA before and after mammographic breast compression in a cohort of breast cancer patients scheduled for neoadjuvant treatment
Towards Better Breast Cancer Diagnostics: Large-scale Profiling of Tumor Transcriptomes
May 23, 2019
Project Project
RNA-seq-Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers in the Population-Based Multicenter SCAN-B Study
May 7, 2018
Project